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Evaluation of liqui...
Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers
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Wang, Y. (author)
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Li, L. (author)
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Douville, C. (author)
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show more...
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Cohen, J. D. (author)
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Yen, T. T. (author)
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Kinde, I. (author)
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- Sundfeldt, Karin, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
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Kjær, S. K. (author)
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Hruban, R. H. (author)
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Shih, I. M. (author)
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Wang, T. L. (author)
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Kurman, R. J. (author)
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Springer, S. (author)
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Ptak, J. (author)
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Popoli, M. (author)
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Schaefer, J. (author)
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Silliman, N. (author)
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Dobbyn, L. (author)
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Tanner, E. J. (author)
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Angarita, A. (author)
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- Lycke, Maria (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
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Jochumsen, K. (author)
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Afsari, B. (author)
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Danilova, L. (author)
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Levine, D. A. (author)
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Jardon, K. (author)
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Zeng, X. (author)
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Arseneau, J. (author)
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Fu, L. (author)
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Diaz, L. A. (author)
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Karchin, R. (author)
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Tomasetti, C. (author)
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Kinzler, K. W. (author)
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Vogelstein, B. (author)
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Fader, A. N. (author)
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Gilbert, L. (author)
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Papadopoulos, N. (author)
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(creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2018
- 2018
- English.
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In: Science Translational Medicine. - : American Association for the Advancement of Science (AAAS). - 1946-6234 .- 1946-6242. ; 10:433, s. 1-9
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- We report the detection of endometrial and ovarian cancers based on genetic analyses of DNA recovered from the fluids obtained during a routine Papanicolaou (Pap) test. The new test, called PapSEEK, incorporates assays for mutations in 18 genes as well as an assay for aneuploidy. In Pap brush samples from 382 endometrial cancer patients, 81% [95% confidence interval (CI), 77 to 85%] were positive, including 78% of patients with early-stage disease. The sensitivity in 245 ovarian cancer patients was 33% (95% CI, 27 to 39%), including 34% of patients with early-stage disease. In contrast, only 1.4% of 714 women without cancer had positive Pap brush samples (specificity, ~99%). Next, we showed that intrauterine sampling with a Tao brush increased the detection of malignancy over endocervical sampling with a Pap brush: 93% of 123 (95% CI, 87 to 97%) patients with endometrial cancer and 45% of 51 (95% CI, 31 to 60%) patients with ovarian cancer were positive, whereas none of the samples from 125 women without cancer were positive (specificity, 100%). Finally, in 83 ovarian cancer patients in whom plasma was available, circulating tumor DNA was found in 43% of patients (95% CI, 33 to 55%). When plasma and Pap brush samples were both tested, the sensitivity for ovarian cancer increased to 63% (95% CI, 51 to 73%). These results demonstrate the potential of mutation-based diagnostics to detect gynecologic cancers at a stage when they are more likely to be curable.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Wang, Y.
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Li, L.
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Douville, C.
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Cohen, J. D.
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Yen, T. T.
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Kinde, I.
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show more...
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Sundfeldt, Karin ...
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Kjær, S. K.
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Hruban, R. H.
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Shih, I. M.
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Wang, T. L.
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Kurman, R. J.
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Springer, S.
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Ptak, J.
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Popoli, M.
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Schaefer, J.
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Silliman, N.
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Dobbyn, L.
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Tanner, E. J.
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Angarita, A.
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Lycke, Maria
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Jochumsen, K.
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Afsari, B.
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Danilova, L.
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Levine, D. A.
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Jardon, K.
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Zeng, X.
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Arseneau, J.
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Fu, L.
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Diaz, L. A.
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Karchin, R.
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Tomasetti, C.
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Kinzler, K. W.
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Vogelstein, B.
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Fader, A. N.
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Gilbert, L.
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Papadopoulos, N.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Science Translat ...
- By the university
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University of Gothenburg